Expandable Polymer Assisted Wearable Personalized Medicinal Platform

Personalized medicine is an emerging therapeutic approach that aims to provide tailor-made therapy based on everyone’s individual needs by delivering the right drug at the right time with the right amount of dosage. Advancement in technologies such as wearable biosensors, point-of-care diagnostics, microfluidics, and artificial intelligence can enable the realization of effective personalized therapy. However, currently, there is a lack of a personalized minimally invasive wearable closed-loop drug delivery system that is continuous, automated, conformal to the skin, and cost-effective. Here, design, fabrication, optimization, and application of a personalized medicinal platform augmented with flexible biosensors, heaters, expandable actuator and processing units powered by a lightweight battery are shown. The platform provides precise drug delivery and preparation with spatiotemporal control over the administered dose as a response to real-time physiological changes of the individual. The system is conformal to the skin, and the drug is transdermally administered through an integrated microneedle. The developed platform is fabricated using rapid, cost-effective techniques that are independent of advanced microfabrication facilities to expand its applications to low-resource environments.

Publications Babatain, W., Gumus, A., Wicaksono, I., Buttner, U., El‐atab, N., Rehman, M.U., Qaiser, N., Conchouso, D. and Hussain, M.M., 2020. Expandable Polymer Assisted Wearable Personalized Medicinal Platform. Advanced Materials Technologies, 5(10), p.2000411. [Cover Article]

Gumus, A., Alam, A., Hussain, A.M., Mishra, K., Wicaksono, I., Torres Sevilla, G.A., Shaikh, S.F., Diaz, M., Velling, S., Ghoneim, M.T. and Ahmed, S.M., 2017. Expandable Polymer Enabled Wirelessly Destructible High‐Performance Solid State Electronics. Advanced Materials Technologies, 2(5), p.1600264.

SXSW Innovation Awards 2022. Finalist: Wearable Category.